HEPATO-RENAL EFFECT OF Solanum anomalum Thonn. Ex. Schumach FRUIT EXTRACTS ON LEAD-EXPOSED ALBINO RATS

Lead is a non-biodegradable multi-organ toxicant implicated in various disorders including renal and hepatic diseases. In the quest for cheaper readily available antidote, this study has investigated role of Solanum anomalum fruit extract lead-induced kidney liver toxicities male albino rats. Twenty-four mature rats were used, divided into four groups six per group. Group 1 (control rats) received distilled water (10 ml/kg), group 2 was given lead acetate solution 60 mg/kg, 3 (60 mg/kg) followed by anomalum, SA (452 4 (678 mg/kg)  oral gavage daily 28 days. Animals acetate-treated showed significant increases ALT, AST, ALP, urea, bilirubin, total cholesterol, triglycerides, Low Density Lipoprotein, Very Lipoproteins, white blood cell counts, Interleukin-6, decreases body weight, packed volume, hemoglobin concentration, red count, proteins albumins. Co-administration significantly reversed most these biomarkers. Histopathology also points to protective effect against induced hepato-renal damage.Keywords: lead, liver, kidney, biomarkers, toxicant.